12/28/2022 0 Comments Sve o biljci davana artemisia pallensand is used as a traditional medicine for the treatment of malaria and other diseases in China. Artemisia annua is a plant species of genus Artemisia L. World Health Organization recommends artemisinin and its derivatives for the treatment of malaria (White 2008). All rights reserved.Artemisinin is a highly potent anti-malarial drug found in the medicinal plant Artemisia annua ( A. Hence, this article proposes D1 as an effective regimen for curtailing the Parkinson disease linked pathologies through mechanism of maintaining cellular redox state and proteostasis.Īrtemisia pallens Caenorhabditis elegans Parkinsonism bicyclogermacrene cis-davanone cis-hydroxy-davanone.Ĭopyright © 2022 Elsevier Inc. elegans PDR-1 with D1 further confirmed its contribution in D1 induced abridgment of Parkinson disease linked pathologies in C. The genetic regulation mediating the above effects validated through the qPCR study showed that D1 supplementation displayed its anti-Parkinson's effect through upregulation of the antioxidant defence system genes (superoxide dismutase (sod)-1, sod-2, and sod-4) and PD associated pdr-1 gene that maintains the mitochondrial proteostasis. elegans validating its future use as a dopamine-enhancing agent. Additionally, D1 modulated dopamine regulated nonanol-1 repulsion and locomotory behaviour of C. The tested compounds alleviated α-synuclein (α-syn) aggregation and maximum decline was observed in 25 μM D1 supplemented worms. pallens, the pharmacological potential of the isolates of the plant, namely bicyclogermacrene (D1), cis-davanone (D3), and cis-hydroxy davanone (D5), was tested for anti-Parkinson's activity in Caenorhabditis elegans model. Given the diverse traditional and scientifically documented therapeutic effects of A. ex DC, commonly known as davana, is an annual aromatic herb cultivated in southern India. Consequently, recent drug development studies are focusing on alternative medicines from plant sources. The current regimen for PD treatment includes synthetic drugs that lack efficacy and cause serious side effects. Parkinson's disease (PD) is a multifactorial ailment that severely affects the viability of dopaminergic neurons leading to progressive loss of motor control.
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